Dose-escalation of human anti-interferon-α receptor monoclonal antibody MEDI-546 in subjects with systemic sclerosis: a phase 1, multicenter, open label study

INTRODUCTION: Type I interferons (IFNs) are implicated in the pathogenesis of systemic sclerosis (SSc). MEDI-546 is an investigational human monoclonal antibody directed against the type I IFN receptor. This Phase 1 study evaluated the safety/tolerability, pharmacokinetics (PK), immunogenicity, and...

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Autores principales: Goldberg, Avram, Geppert, Thomas, Schiopu, Elena, Frech, Tracy, Hsu, Vivien, Simms, Robert W, Peng, Stanford L, Yao, Yihong, Elgeioushi, Nairouz, Chang, Linda, Wang, Bing, Yoo, Stephen
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978926/
https://ncbi.nlm.nih.gov/pubmed/24559157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4492
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