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Filtering genetic variants and placing informative priors based on putative biological function

High-density genetic marker data, especially sequence data, imply an immense multiple testing burden. This can be ameliorated by filtering genetic variants, exploiting or accounting for correlations between variants, jointly testing variants, and by incorporating informative priors. Priors can be ba...

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Bibliografiska uppgifter
I publikationen:BMC Genet
Huvudupphovsmän: Friedrichs, Stefanie, Malzahn, Dörthe, Pugh, Elizabeth W., Almeida, Marcio, Liu, Xiao Qing, Bailey, Julia N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4895695/
https://ncbi.nlm.nih.gov/pubmed/26866982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12863-015-0313-x
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