USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2

Histone deacetylases (HDACs) are major epigenetic modulators involved in a broad spectrum of human diseases including cancers. As HDACs are promising targets of cancer therapy, it is important to understand the mechanisms of HDAC regulation. In this study, we show that ubiquitin-specific peptidase 4...

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發表在:Oncogene
Main Authors: Li, Z, Hao, Q, Luo, J, Xiong, J, Zhang, S, Wang, T, Bai, L, Wang, W, Chen, M, Gu, L, Lv, K, Chen, J
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2016
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4895393/
https://ncbi.nlm.nih.gov/pubmed/26411366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.349
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