USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2

Histone deacetylases (HDACs) are major epigenetic modulators involved in a broad spectrum of human diseases including cancers. As HDACs are promising targets of cancer therapy, it is important to understand the mechanisms of HDAC regulation. In this study, we show that ubiquitin-specific peptidase 4...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncogene
Prif Awduron: Li, Z, Hao, Q, Luo, J, Xiong, J, Zhang, S, Wang, T, Bai, L, Wang, W, Chen, M, Gu, L, Lv, K, Chen, J
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4895393/
https://ncbi.nlm.nih.gov/pubmed/26411366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.349
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