Rational design of a protein that binds integrin α(v)β(3) outside the ligand binding site

Integrin α(v)β(3) expression is altered in various diseases and has been proposed as a drug target. Here we use a rational design approach to develop a therapeutic protein, which we call ProAgio, that binds to integrin α(v)β(3) outside the classical ligand-binding site. We show ProAgio induces apopt...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Turaga, Ravi Chakra, Yin, Lu, Yang, Jenny J., Lee, Hsiauwei, Ivanov, Ivaylo, Yan, Chunli, Yang, Hua, Grossniklaus, Hans E., Wang, Siming, Ma, Cheng, Sun, Li, Liu, Zhi-Ren
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4895024/
https://ncbi.nlm.nih.gov/pubmed/27241473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11675
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