Modulation of Cancer-Associated Fibrotic Stroma by An Integrin α(v)β(3) Targeting Protein for Pancreatic Cancer Treatment

BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDAC) is resistant to most therapeutics owing to dense fibrotic stroma orchestrated by cancer-associated pancreatic stellate cells (CAPaSC). CAPaSC also support cancer cell growth, metastasis, and resistance to apoptosis. Currently, there is n...

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Veröffentlicht in:Cell Mol Gastroenterol Hepatol
Hauptverfasser: Turaga, Ravi Chakra, Sharma, Malvika, Mishra, Falguni, Krasinskas, Alyssa, Yuan, Yi, Yang, Jenny J., Wang, Shiyuan, Liu, Chunfeng, Li, Sun, Liu, Zhi-Ren
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674520/
https://ncbi.nlm.nih.gov/pubmed/32810598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2020.08.004
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