Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Ferroptosis is a non-apoptotic form of cell death induced by small molecules in specific tumour types, and in engineered cells overexpressing oncogenic RAS. Yet, its relevance in non-transformed cells and tissues is unexplored and remains enigmatic. Here, we provide direct genetic evidence that the...

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Bibliografske podrobnosti
izdano v:Nat Cell Biol
Main Authors: Angeli, Jose Pedro Friedmann, Schneider, Manuela, Proneth, Bettina, Tyurina, Yulia Y., Tyurin, Vladimir A., Hammond, Victoria J., Herbach, Nadja, Aichler, Michaela, Walch, Axel, Eggenhofer, Elke, Basavarajappa, Devaraj, Rådmark, Olof, Kobayashi, Sho, Seibt, Tobias, Beck, Heike, Neff, Frauke, Esposito, Irene, Wanke, Rüdiger, Förster, Heidi, Yefremova, Olena, Heinrichmeyer, Marc, Bornkamm, Georg W., Geissler, Edward K., Thomas, Stephen B., Stockwell, Brent R., O’Donnell, Valerie B., Kagan, Valerian E., Schick, Joel A., Conrad, Marcus
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894846/
https://ncbi.nlm.nih.gov/pubmed/25402683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3064
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