Acsl4 Dictates Ferroptosis Sensitivity by Shaping Cellular Lipid Composition

Ferroptosis is a form of regulated necrotic cell death controlled by glutathione peroxidase 4 (GPX4). At present, mechanisms that could predict sensitivity and/or resistance and that may be exploited to modulate this form of cell death are needed. We applied two independent approaches, a genome-wide...

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Publicado no:Nat Chem Biol
Main Authors: Doll, Sebastian, Proneth, Bettina, Tyurina, Yulia Y., Panzilius, Elena, Kobayashi, Sho, Ingold, Irina, Irmler, Martin, Beckers, Johannes, Aichler, Michaela, Walch, Axel, Prokisch, Holger, Trümbach, Dietrich, Mao, Gaowei, Qu, Feng, Bayir, Hulya, Füllekrug, Joachim, Scheel, Christine, Wurst, Wolfgang, Schick, Joel A., Kagan, Valerian E., Angeli, José Pedro Friedmann, Conrad, Marcus
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610546/
https://ncbi.nlm.nih.gov/pubmed/27842070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2239
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