Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility

The selenoenzyme Gpx4 is essential for early embryogenesis and cell viability for its unique function to prevent phospholipid oxidation. Recently, the cytosolic form of Gpx4 was identified as an upstream regulator of a novel form of non-apoptotic cell death, called ferroptosis, whereas the mitochond...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ingold, Irina, Aichler, Michaela, Yefremova, Elena, Roveri, Antonella, Buday, Katalin, Doll, Sebastian, Tasdemir, Adrianne, Hoffard, Nils, Wurst, Wolfgang, Walch, Axel, Ursini, Fulvio, Friedmann Angeli, José Pedro, Conrad, Marcus
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505533/
https://ncbi.nlm.nih.gov/pubmed/25922076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.656363
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