Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility

The selenoenzyme Gpx4 is essential for early embryogenesis and cell viability for its unique function to prevent phospholipid oxidation. Recently, the cytosolic form of Gpx4 was identified as an upstream regulator of a novel form of non-apoptotic cell death, called ferroptosis, whereas the mitochond...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Ingold, Irina, Aichler, Michaela, Yefremova, Elena, Roveri, Antonella, Buday, Katalin, Doll, Sebastian, Tasdemir, Adrianne, Hoffard, Nils, Wurst, Wolfgang, Walch, Axel, Ursini, Fulvio, Friedmann Angeli, José Pedro, Conrad, Marcus
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2015
Konular:
Enzymology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505533/
https://ncbi.nlm.nih.gov/pubmed/25922076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.656363
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