Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility

The selenoenzyme Gpx4 is essential for early embryogenesis and cell viability for its unique function to prevent phospholipid oxidation. Recently, the cytosolic form of Gpx4 was identified as an upstream regulator of a novel form of non-apoptotic cell death, called ferroptosis, whereas the mitochond...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Ingold, Irina, Aichler, Michaela, Yefremova, Elena, Roveri, Antonella, Buday, Katalin, Doll, Sebastian, Tasdemir, Adrianne, Hoffard, Nils, Wurst, Wolfgang, Walch, Axel, Ursini, Fulvio, Friedmann Angeli, José Pedro, Conrad, Marcus
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Enzymology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505533/
https://ncbi.nlm.nih.gov/pubmed/25922076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.656363
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