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FINO(2) Initiates Ferroptosis Through GPX4 Inactivation and Iron Oxidation
Ferroptosis is a non-apoptotic form of regulated cell death caused by the failure of the glutathione-dependent lipid-peroxide-scavenging network. FINO(2) is an endoperoxide-containing 1,2-dioxolane that can initiate ferroptosis selectively in engineered cancer cells. We investigated the mechanism an...
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| Foilsithe in: | Nat Chem Biol |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2018
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5899674/ https://ncbi.nlm.nih.gov/pubmed/29610484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-018-0031-6 |
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