EGFR fusions as novel therapeutic targets in lung cancer

Here, we report that novel epidermal growth factor receptor (EGFR) gene fusions comprising the N-terminal of EGFR linked to various fusion partners, most commonly RAD51, are recurrent in lung cancer. We describe five patients with metastatic lung cancer whose tumors harbored EGFR fusions, four of wh...

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Publicat a:Cancer Discov
Autors principals: Konduri, Kartik, Gallant, Jean-Nicolas, Chae, Young Kwang, Giles, Francis J., Gitlitz, Barbara J., Gowen, Kyle, Ichihara, Eiki, Owonikoko, Taofeek K., Peddareddigari, Vijay, Ramalingam, Suresh S., Reddy, Satyanarayan K., Eaby-Sandy, Beth, Vavalà, Tiziana, Whiteley, Andrew, Chen, Heidi, Yan, Yingjun, Sheehan, Jonathan H., Meiler, Jens, Morosini, Deborah, Ross, Jeffrey S., Stephens, Philip J., Miller, Vincent A., Ali, Siraj M., Lovly, Christine M.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893907/
https://ncbi.nlm.nih.gov/pubmed/27102076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0075
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