EGFR fusions as novel therapeutic targets in lung cancer

Here, we report that novel epidermal growth factor receptor (EGFR) gene fusions comprising the N-terminal of EGFR linked to various fusion partners, most commonly RAD51, are recurrent in lung cancer. We describe five patients with metastatic lung cancer whose tumors harbored EGFR fusions, four of wh...

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Publicado no:Cancer Discov
Main Authors: Konduri, Kartik, Gallant, Jean-Nicolas, Chae, Young Kwang, Giles, Francis J., Gitlitz, Barbara J., Gowen, Kyle, Ichihara, Eiki, Owonikoko, Taofeek K., Peddareddigari, Vijay, Ramalingam, Suresh S., Reddy, Satyanarayan K., Eaby-Sandy, Beth, Vavalà, Tiziana, Whiteley, Andrew, Chen, Heidi, Yan, Yingjun, Sheehan, Jonathan H., Meiler, Jens, Morosini, Deborah, Ross, Jeffrey S., Stephens, Philip J., Miller, Vincent A., Ali, Siraj M., Lovly, Christine M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893907/
https://ncbi.nlm.nih.gov/pubmed/27102076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0075
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