EGFR fusions as novel therapeutic targets in lung cancer

Here, we report that novel epidermal growth factor receptor (EGFR) gene fusions comprising the N-terminal of EGFR linked to various fusion partners, most commonly RAD51, are recurrent in lung cancer. We describe five patients with metastatic lung cancer whose tumors harbored EGFR fusions, four of wh...

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Gepubliceerd in:Cancer Discov
Hoofdauteurs: Konduri, Kartik, Gallant, Jean-Nicolas, Chae, Young Kwang, Giles, Francis J., Gitlitz, Barbara J., Gowen, Kyle, Ichihara, Eiki, Owonikoko, Taofeek K., Peddareddigari, Vijay, Ramalingam, Suresh S., Reddy, Satyanarayan K., Eaby-Sandy, Beth, Vavalà, Tiziana, Whiteley, Andrew, Chen, Heidi, Yan, Yingjun, Sheehan, Jonathan H., Meiler, Jens, Morosini, Deborah, Ross, Jeffrey S., Stephens, Philip J., Miller, Vincent A., Ali, Siraj M., Lovly, Christine M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893907/
https://ncbi.nlm.nih.gov/pubmed/27102076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0075
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