Ca(2+) is a key factor in α-synuclein-induced neurotoxicity

Aggregation of α-synuclein leads to the formation of oligomeric intermediates that can interact with membranes to form pores. However, it is unknown how this leads to cell toxicity in Parkinson's disease. We investigated the species-specific effects of α-synuclein on Ca(2+) signalling in primar...

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Библиографические подробности
Опубликовано в: :J Cell Sci
Главные авторы: Angelova, Plamena R., Ludtmann, Marthe H. R., Horrocks, Mathew H., Negoda, Alexander, Cremades, Nunilo, Klenerman, David, Dobson, Christopher M., Wood, Nicholas W., Pavlov, Evgeny V., Gandhi, Sonia, Abramov, Andrey Y.
Формат: Artigo
Язык:Inglês
Опубликовано: The Company of Biologists Ltd 2016
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893653/
https://ncbi.nlm.nih.gov/pubmed/26989132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.180737
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