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Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading
The protein alpha-synuclein (αS) self-assembles into small oligomeric species and subsequently into amyloid fibrils that accumulate and proliferate during the development of Parkinson’s disease. However, the quantitative characterization of the aggregation and spreading of αS remains challenging to...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4780632/ https://ncbi.nlm.nih.gov/pubmed/26884195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524128113 |
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