Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

The protein alpha-synuclein (αS) self-assembles into small oligomeric species and subsequently into amyloid fibrils that accumulate and proliferate during the development of Parkinson’s disease. However, the quantitative characterization of the aggregation and spreading of αS remains challenging to...

詳細記述

保存先:
書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Iljina, Marija, Garcia, Gonzalo A., Horrocks, Mathew H., Tosatto, Laura, Choi, Minee L., Ganzinger, Kristina A., Abramov, Andrey Y., Gandhi, Sonia, Wood, Nicholas W., Cremades, Nunilo, Dobson, Christopher M., Knowles, Tuomas P. J., Klenerman, David
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2016
主題:
PNAS Plus
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780632/
https://ncbi.nlm.nih.gov/pubmed/26884195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524128113
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