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Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading
The protein alpha-synuclein (αS) self-assembles into small oligomeric species and subsequently into amyloid fibrils that accumulate and proliferate during the development of Parkinson’s disease. However, the quantitative characterization of the aggregation and spreading of αS remains challenging to...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4780632/ https://ncbi.nlm.nih.gov/pubmed/26884195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524128113 |
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