Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

The protein alpha-synuclein (αS) self-assembles into small oligomeric species and subsequently into amyloid fibrils that accumulate and proliferate during the development of Parkinson’s disease. However, the quantitative characterization of the aggregation and spreading of αS remains challenging to...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Iljina, Marija, Garcia, Gonzalo A., Horrocks, Mathew H., Tosatto, Laura, Choi, Minee L., Ganzinger, Kristina A., Abramov, Andrey Y., Gandhi, Sonia, Wood, Nicholas W., Cremades, Nunilo, Dobson, Christopher M., Knowles, Tuomas P. J., Klenerman, David
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780632/
https://ncbi.nlm.nih.gov/pubmed/26884195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524128113
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