Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

The protein alpha-synuclein (αS) self-assembles into small oligomeric species and subsequently into amyloid fibrils that accumulate and proliferate during the development of Parkinson’s disease. However, the quantitative characterization of the aggregation and spreading of αS remains challenging to...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Iljina, Marija, Garcia, Gonzalo A., Horrocks, Mathew H., Tosatto, Laura, Choi, Minee L., Ganzinger, Kristina A., Abramov, Andrey Y., Gandhi, Sonia, Wood, Nicholas W., Cremades, Nunilo, Dobson, Christopher M., Knowles, Tuomas P. J., Klenerman, David
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780632/
https://ncbi.nlm.nih.gov/pubmed/26884195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524128113
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