Adenovirus-mediated downregulation of the ubiquitin ligase RNF8 sensitizes bladder cancer to radiotherapy

The ubiquitin ligase RNF8 promotes the DNA damage response (DDR). We observed that the expression of RNF8 was increased in bladder cancer cells and that this change in RNF8 expression could be reversed by adenovirus-mediated shRNA treatment. Moreover, we found that RNF8 knockdown sensitized bladder...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Zhao, Mei-Jun, Song, Yan-Feng, Niu, Hai-Tao, Tian, Ying-Xia, Yang, Xu-Guang, Xie, Kun, Jing, Yu-Hong, Wang, De-Gui
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891017/
https://ncbi.nlm.nih.gov/pubmed/26788910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6909
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