Adenovirus-mediated downregulation of the ubiquitin ligase RNF8 sensitizes bladder cancer to radiotherapy

The ubiquitin ligase RNF8 promotes the DNA damage response (DDR). We observed that the expression of RNF8 was increased in bladder cancer cells and that this change in RNF8 expression could be reversed by adenovirus-mediated shRNA treatment. Moreover, we found that RNF8 knockdown sensitized bladder...

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Pubblicato in:Oncotarget
Autori principali: Zhao, Mei-Jun, Song, Yan-Feng, Niu, Hai-Tao, Tian, Ying-Xia, Yang, Xu-Guang, Xie, Kun, Jing, Yu-Hong, Wang, De-Gui
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891017/
https://ncbi.nlm.nih.gov/pubmed/26788910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6909
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