Adenovirus-mediated downregulation of the ubiquitin ligase RNF8 sensitizes bladder cancer to radiotherapy

The ubiquitin ligase RNF8 promotes the DNA damage response (DDR). We observed that the expression of RNF8 was increased in bladder cancer cells and that this change in RNF8 expression could be reversed by adenovirus-mediated shRNA treatment. Moreover, we found that RNF8 knockdown sensitized bladder...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zhao, Mei-Jun, Song, Yan-Feng, Niu, Hai-Tao, Tian, Ying-Xia, Yang, Xu-Guang, Xie, Kun, Jing, Yu-Hong, Wang, De-Gui
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891017/
https://ncbi.nlm.nih.gov/pubmed/26788910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6909
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