Pancreatitis-induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence

Pancreatic acinar cells of adult mice (≥P60) are resistant to transformation by some of the most robust oncogenic insults including expression of K-Ras oncogenes and loss of p16Ink4a/p19Arf or Trp53 tumor suppressors. Yet, these acinar cells yield pancreatic intraepithelial neoplasias (mPanIN) and d...

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Publicat a:Cancer Cell
Autors principals: Guerra, Carmen, Collado, Manuel, Navas, Carolina, Schuhmacher, Alberto J, Hernández-Porras, Isabel, Cañamero, Marta, Rodriguez-Justo, Manuel, Serrano, Manuel, Barbacid, Mariano
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890723/
https://ncbi.nlm.nih.gov/pubmed/21665147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.05.011
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