A mouse model for Costello syndrome reveals an Ang II–mediated hypertensive condition

Germline activation of H-RAS oncogenes is the primary cause of Costello syndrome (CS), a neuro-cardio-facio-cutaneous developmental syndrome. Here we describe the generation of a mouse model of CS by introduction of an oncogenic Gly12Val mutation in the mouse H-Ras locus using homologous recombinati...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Schuhmacher, Alberto J., Guerra, Carmen, Sauzeau, Vincent, Cañamero, Marta, Bustelo, Xosé R., Barbacid, Mariano
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2008
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2381749/
https://ncbi.nlm.nih.gov/pubmed/18483625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34385
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars