A mouse model for Costello syndrome reveals an Ang II–mediated hypertensive condition

Germline activation of H-RAS oncogenes is the primary cause of Costello syndrome (CS), a neuro-cardio-facio-cutaneous developmental syndrome. Here we describe the generation of a mouse model of CS by introduction of an oncogenic Gly12Val mutation in the mouse H-Ras locus using homologous recombinati...

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Main Authors: Schuhmacher, Alberto J., Guerra, Carmen, Sauzeau, Vincent, Cañamero, Marta, Bustelo, Xosé R., Barbacid, Mariano
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2381749/
https://ncbi.nlm.nih.gov/pubmed/18483625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34385
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