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A mouse model for Costello syndrome reveals an Ang II–mediated hypertensive condition
Germline activation of H-RAS oncogenes is the primary cause of Costello syndrome (CS), a neuro-cardio-facio-cutaneous developmental syndrome. Here we describe the generation of a mouse model of CS by introduction of an oncogenic Gly12Val mutation in the mouse H-Ras locus using homologous recombinati...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Clinical Investigation
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2381749/ https://ncbi.nlm.nih.gov/pubmed/18483625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34385 |
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