Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome

RASopathies are a class of developmental syndromes that result from congenital mutations in key elements of the RAS/RAF/MEK signaling pathway. A well-recognized RASopathy is the cardio-facio-cutaneous (CFC) syndrome characterized by a distinctive facial appearance, heart defects, and mental retardat...

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Detalhes bibliográficos
Main Authors: Urosevic, Jelena, Sauzeau, Vincent, Soto-Montenegro, María L., Reig, Santiago, Desco, Manuel, Wright, Emma M. Burkitt, Cañamero, Marta, Mulero, Francisca, Ortega, Sagrario, Bustelo, Xosé R., Barbacid, Mariano
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064394/
https://ncbi.nlm.nih.gov/pubmed/21383153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016933108
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