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c-Raf, but not B-Raf, is essential for development of K-Ras oncogene driven non-small cell lung carcinoma
We have interrogated the role of individual members of the Raf/Mek/Erk cascade in the onset of K-Ras oncogene-driven non-small cell lung carcinoma (NSCLC). Ablation of Erk1 or Erk2 in K-Ras oncogene expressing lung cells had no significant effect due to compensatory activities. Yet, elimination of b...
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| Pubblicato in: | Cancer Cell |
|---|---|
| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4854330/ https://ncbi.nlm.nih.gov/pubmed/21514245 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.04.002 |
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