c-Raf, but not B-Raf, is essential for development of K-Ras oncogene driven non-small cell lung carcinoma

We have interrogated the role of individual members of the Raf/Mek/Erk cascade in the onset of K-Ras oncogene-driven non-small cell lung carcinoma (NSCLC). Ablation of Erk1 or Erk2 in K-Ras oncogene expressing lung cells had no significant effect due to compensatory activities. Yet, elimination of b...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Blasco, Rafael B., Francoz, Sarah, Santamaría, David, Cañamero, Marta, Dubus, Pierre, Charron, Jean, Baccarini, Manuela, Barbacid, Mariano
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854330/
https://ncbi.nlm.nih.gov/pubmed/21514245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.04.002
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