EGF RECEPTOR SIGNALING IS ESSENTIAL FOR K-RAS ONCOGENE-DRIVEN PANCREATIC DUCTAL ADENOCARCINOMA

Clinical evidence indicates that mutation/activation of EGF receptors (EGFRs) is mutually exclusive with the presence of K-RAS oncogenes in lung and colon tumors. We have validated these observations using genetically engineered mouse models. However, pancreatic ductal adenocarcinomas driven by K-Ra...

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Hlavní autoři: Navas, Carolina, Hernández-Porras, Isabel, Schuhmacher, Alberto J, Sibilia, Maria, Guerra, Carmen, Barbacid, Mariano
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601542/
https://ncbi.nlm.nih.gov/pubmed/22975375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.08.001
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