A General Synthetic Approach for Designing Epitope Targeted Macrocyclic Peptide Ligands

We describe a general synthetic strategy for developing high affinity peptide binders against specific epitopes of challenging protein biomarkers. The epitope of interest is synthesized as a polypeptide, with a detection biotin tag and a strategically placed azide (or alkyne) presenting amino acid....

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Dades bibliogràfiques
Publicat a:Angew Chem Int Ed Engl
Autors principals: Das, Samir, Nag, Arundhati, Liang, JingXin, Bunck, David N., Umeda, Aiko, Farrow, Blake, Coppock, Matthew B., Sarkes, Deborah A., Finch, Amethist S., Agnew, Heather D., Pitram, Suresh, Lai, Bert, Yu, Mary Beth, Museth, Katrine, Deyle, Kaycie M., Lepe, Bianca, Rodriguez-Rivera, Francis P, McCarthy, Amy, Alvarez-Villalonga, Belen, Chen, Ann, Heath, John, Stratis-Cullum, Dimitra N., Heath, James R.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890538/
https://ncbi.nlm.nih.gov/pubmed/26377818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201505243
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