A General Synthetic Approach for Designing Epitope Targeted Macrocyclic Peptide Ligands

We describe a general synthetic strategy for developing high affinity peptide binders against specific epitopes of challenging protein biomarkers. The epitope of interest is synthesized as a polypeptide, with a detection biotin tag and a strategically placed azide (or alkyne) presenting amino acid....

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Das, Samir, Nag, Arundhati, Liang, JingXin, Bunck, David N., Umeda, Aiko, Farrow, Blake, Coppock, Matthew B., Sarkes, Deborah A., Finch, Amethist S., Agnew, Heather D., Pitram, Suresh, Lai, Bert, Yu, Mary Beth, Museth, Katrine, Deyle, Kaycie M., Lepe, Bianca, Rodriguez-Rivera, Francis P, McCarthy, Amy, Alvarez-Villalonga, Belen, Chen, Ann, Heath, John, Stratis-Cullum, Dimitra N., Heath, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890538/
https://ncbi.nlm.nih.gov/pubmed/26377818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201505243
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados