A General Synthetic Approach for Designing Epitope Targeted Macrocyclic Peptide Ligands

We describe a general synthetic strategy for developing high affinity peptide binders against specific epitopes of challenging protein biomarkers. The epitope of interest is synthesized as a polypeptide, with a detection biotin tag and a strategically placed azide (or alkyne) presenting amino acid....

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Das, Samir, Nag, Arundhati, Liang, JingXin, Bunck, David N., Umeda, Aiko, Farrow, Blake, Coppock, Matthew B., Sarkes, Deborah A., Finch, Amethist S., Agnew, Heather D., Pitram, Suresh, Lai, Bert, Yu, Mary Beth, Museth, Katrine, Deyle, Kaycie M., Lepe, Bianca, Rodriguez-Rivera, Francis P, McCarthy, Amy, Alvarez-Villalonga, Belen, Chen, Ann, Heath, John, Stratis-Cullum, Dimitra N., Heath, James R.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890538/
https://ncbi.nlm.nih.gov/pubmed/26377818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201505243
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