טוען...
Protein-targeting strategy used to develop a selective inhibitor of the E17K point mutation in the PH Domain of Akt1
Ligands that can selectively bind to proteins with single amino acid point mutations offer the potential to detect or treat an abnormal protein in the presence of the wildtype. However, it is difficult to develop a selective ligand if the point mutation is not associated with an addressable location...
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| הוצא לאור ב: | Nat Chem |
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| Main Authors: | , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2015
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4408887/ https://ncbi.nlm.nih.gov/pubmed/25901825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.2223 |
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