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Epitope-Targeting of Tertiary Protein Structure Enables Target-Guided Synthesis of a Potent in Cell Inhibitor of Botulinum Neurotoxin
Botulinum neurotoxin (BoNT) serotype A is the most lethal known toxin and has an occluded structure which prevents direct inhibition of its active site before it enters the cytosol. We combine in situ click target-guided synthesis with synthetic epitope-targeting to exploit the tertiary structure of...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5444873/ https://ncbi.nlm.nih.gov/pubmed/25925721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201502451 |
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