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Epitope-Targeting of Tertiary Protein Structure Enables Target-Guided Synthesis of a Potent in Cell Inhibitor of Botulinum Neurotoxin

Botulinum neurotoxin (BoNT) serotype A is the most lethal known toxin and has an occluded structure which prevents direct inhibition of its active site before it enters the cytosol. We combine in situ click target-guided synthesis with synthetic epitope-targeting to exploit the tertiary structure of...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Farrow, Blake, Wong, Michelle, Malette, Jacquie, Lai, Bert, Deyle, Kaycie M., Das, Samir, Nag, Arundhati, Agnew, Heather D., Heath, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444873/
https://ncbi.nlm.nih.gov/pubmed/25925721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201502451
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