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Degradation of Akt Using Protein Catalyzed Capture Agents
Abnormal signaling of the protein kinase Akt has been shown to contribute to human diseases such as diabetes and cancer, but Akt has proven to be a challenging target for drugging. Using iterative in situ click chemistry we recently developed multiple protein catalyzed capture (PCC) agents that allo...
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| Udgivet i: | J Pept Sci |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4883657/ https://ncbi.nlm.nih.gov/pubmed/26880702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psc.2858 |
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