Degradation of Akt Using Protein Catalyzed Capture Agents

Abnormal signaling of the protein kinase Akt has been shown to contribute to human diseases such as diabetes and cancer, but Akt has proven to be a challenging target for drugging. Using iterative in situ click chemistry we recently developed multiple protein catalyzed capture (PCC) agents that allo...

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Bibliografski detalji
Izdano u:J Pept Sci
Glavni autori: Henning, Ryan K., Varghese, Joseph O., Das, Samir, Nag, Arundhati, Tang, Grace, Tang, Kevin, Sutherland, Alexander M., Heath, James R.
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4883657/
https://ncbi.nlm.nih.gov/pubmed/26880702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psc.2858
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