Degradation of Akt Using Protein Catalyzed Capture Agents

Abnormal signaling of the protein kinase Akt has been shown to contribute to human diseases such as diabetes and cancer, but Akt has proven to be a challenging target for drugging. Using iterative in situ click chemistry we recently developed multiple protein catalyzed capture (PCC) agents that allo...

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Bibliografiska uppgifter
I publikationen:J Pept Sci
Huvudupphovsmän: Henning, Ryan K., Varghese, Joseph O., Das, Samir, Nag, Arundhati, Tang, Grace, Tang, Kevin, Sutherland, Alexander M., Heath, James R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4883657/
https://ncbi.nlm.nih.gov/pubmed/26880702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psc.2858
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