Iterative In situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1

We describe the use of iterative in situ click chemistry to design an Akt-specific branched peptide triligand that is a drop-in replacement for monoclonal antibodies in multiple biochemical assays. Each peptide module in the branched structure makes unique contributions to affinity and/or specificit...

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Main Authors: Millward, Steven W., Henning, Ryan K., Kwong, Gabriel A., Pitram, Suresh, Agnew, Heather D., Deyle, Kaycie M., Nag, Arundhati, Hein, Jason, Lee, Su Seong, Lim, Jaehong, Pfeilsticker, Jessica A., Sharpless, K. Barry, Heath, James R.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651860/
https://ncbi.nlm.nih.gov/pubmed/21962254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2064389
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