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Formation of Chromosomal Domains by Loop Extrusion
Topologically Associating Domains (TADs) are fundamental structural and functional building blocks of human interphase chromosomes, yet mechanisms of TAD formation remain unclear. Here we propose that loop extrusion underlies TAD formation. In this process, cis-acting loop-extruding factors, likely...
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| Publicado en: | Cell Rep |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4889513/ https://ncbi.nlm.nih.gov/pubmed/27210764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.04.085 |
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