Formation of Chromosomal Domains by Loop Extrusion

Topologically Associating Domains (TADs) are fundamental structural and functional building blocks of human interphase chromosomes, yet mechanisms of TAD formation remain unclear. Here we propose that loop extrusion underlies TAD formation. In this process, cis-acting loop-extruding factors, likely...

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Bibliografiske detaljer
Udgivet i:Cell Rep
Main Authors: Fudenberg, Geoffrey, Imakaev, Maxim, Lu, Carolyn, Goloborodko, Anton, Abdennur, Nezar, Mirny, Leonid A.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889513/
https://ncbi.nlm.nih.gov/pubmed/27210764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.04.085
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