Formation of Chromosomal Domains by Loop Extrusion

Topologically Associating Domains (TADs) are fundamental structural and functional building blocks of human interphase chromosomes, yet mechanisms of TAD formation remain unclear. Here we propose that loop extrusion underlies TAD formation. In this process, cis-acting loop-extruding factors, likely...

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Detaylı Bibliyografya
Yayımlandı:Cell Rep
Asıl Yazarlar: Fudenberg, Geoffrey, Imakaev, Maxim, Lu, Carolyn, Goloborodko, Anton, Abdennur, Nezar, Mirny, Leonid A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889513/
https://ncbi.nlm.nih.gov/pubmed/27210764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.04.085
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