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Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of hNa(V)1.7

Improper function of voltage-gated sodium channels (Na(V)s), obligatory membrane proteins for bioelectrical signaling, has been linked to a number of human pathologies. Small-molecule agents that target Na(V)s hold considerable promise for treatment of chronic disease. Absent a comprehensive underst...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Proc Natl Acad Sci U S A
मुख्य लेखकों: Thomas-Tran, Rhiannon, Du Bois, J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2016
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889396/
https://ncbi.nlm.nih.gov/pubmed/27162340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603486113
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