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Divergent Synthesis of Natural Derivatives of (+)-Saxitoxin Including 11-Saxitoxinethanoic Acid
The bis-guanidinium toxins are a collection of natural products that display nanomolar potency against select isoforms of eukaryotic voltage-gated Na(+) ion channels. We describe a synthetic strategy that enables access to four of these poisons, including 11-saxitoxinethanoic acid, C13-acetoxy saxit...
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| Publicado en: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6426452/ https://ncbi.nlm.nih.gov/pubmed/30488599 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201811717 |
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