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Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of hNa(V)1.7
Improper function of voltage-gated sodium channels (Na(V)s), obligatory membrane proteins for bioelectrical signaling, has been linked to a number of human pathologies. Small-molecule agents that target Na(V)s hold considerable promise for treatment of chronic disease. Absent a comprehensive underst...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4889396/ https://ncbi.nlm.nih.gov/pubmed/27162340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603486113 |
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