Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Na(v)1.7)

Human nociceptive voltage-gated sodium channel (Na(v)1.7), a target of significant interest for the development of antinociceptive agents, is blocked by low nanomolar concentrations of (−)-tetrodotoxin(TTX) but not (+)-saxitoxin (STX) and (+)-gonyautoxin-III (GTX-III). These findings question the lo...

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Bibliografische gegevens
Hoofdauteurs: Walker, James R., Novick, Paul A., Parsons, William H., McGregor, Malcolm, Zablocki, Jeff, Pande, Vijay S., Du Bois, J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2012
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497785/
https://ncbi.nlm.nih.gov/pubmed/23077250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206952109
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