Low concentrations of tetrodotoxin interact with tetrodotoxin-resistant voltage-gated sodium channels

BACKGROUND AND PURPOSE: Tetrodotoxin (TTX) is used to distinguish between two classes of voltage-gated sodium channel (VGSC)—TTX sensitive (TTXS) and TTX resistant (TTXR). The resistance of TTXR VGSCs is thought to result from a low binding affinity of TTX, although at high TTX concentrations channe...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Farmer, C E, Smith, K J, Docherty, R J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2008
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527855/
https://ncbi.nlm.nih.gov/pubmed/18552876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.235
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