GSH-dependent antioxidant defense contributes to the acclimation of colon cancer cells to acidic microenvironment

Due to increased glycolysis and poor local perfusion, solid tumors are usually immersed in an acidic microenvironment. While extracellular acidosis is cytotoxic, cancer cells eventually become acclimated to it. While previous studies have addressed the acute effect of acidosis on cancer cells, littl...

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Vydáno v:Cell Cycle
Hlavní autoři: Zhao, Minnan, Liu, Qiao, Gong, Yanchao, Xu, Xiuhua, Zhang, Chen, Liu, Xiaojie, Zhang, Caibo, Guo, Haiyang, Zhang, Xiyu, Gong, Yaoqin, Shao, Changshun
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2016
Témata:
Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889284/
https://ncbi.nlm.nih.gov/pubmed/26950675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1158374
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