GSH-dependent antioxidant defense contributes to the acclimation of colon cancer cells to acidic microenvironment

Due to increased glycolysis and poor local perfusion, solid tumors are usually immersed in an acidic microenvironment. While extracellular acidosis is cytotoxic, cancer cells eventually become acclimated to it. While previous studies have addressed the acute effect of acidosis on cancer cells, littl...

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Dettagli Bibliografici
Pubblicato in:Cell Cycle
Autori principali: Zhao, Minnan, Liu, Qiao, Gong, Yanchao, Xu, Xiuhua, Zhang, Chen, Liu, Xiaojie, Zhang, Caibo, Guo, Haiyang, Zhang, Xiyu, Gong, Yaoqin, Shao, Changshun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2016
Soggetti:
Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889284/
https://ncbi.nlm.nih.gov/pubmed/26950675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1158374
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