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GSH-dependent antioxidant defense contributes to the acclimation of colon cancer cells to acidic microenvironment

Due to increased glycolysis and poor local perfusion, solid tumors are usually immersed in an acidic microenvironment. While extracellular acidosis is cytotoxic, cancer cells eventually become acclimated to it. While previous studies have addressed the acute effect of acidosis on cancer cells, littl...

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Detalles Bibliográficos
Publicado en:Cell Cycle
Main Authors: Zhao, Minnan, Liu, Qiao, Gong, Yanchao, Xu, Xiuhua, Zhang, Chen, Liu, Xiaojie, Zhang, Caibo, Guo, Haiyang, Zhang, Xiyu, Gong, Yaoqin, Shao, Changshun
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889284/
https://ncbi.nlm.nih.gov/pubmed/26950675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1158374
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