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Backbone Flexibility Influences Nucleotide Incorporation by Human Translesion DNA Polymerase η Opposite Intrastrand Cross-linked DNA
Intrastrand cross-links (IaCL) connecting two purine nucleobases in DNA pose a challenge to high fidelity replication in the cell. Various repair pathways or polymerase bypass can cope with these lesions. The influence of the phosphodiester linkage between two neighbouring 2′-deoxyguanosine (dG) res...
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| Udgivet i: | Biochemistry |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4889123/ https://ncbi.nlm.nih.gov/pubmed/26624500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01078 |
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