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Backbone Flexibility Influences Nucleotide Incorporation by Human Translesion DNA Polymerase η Opposite Intrastrand Cross-linked DNA
Intrastrand cross-links (IaCL) connecting two purine nucleobases in DNA pose a challenge to high fidelity replication in the cell. Various repair pathways or polymerase bypass can cope with these lesions. The influence of the phosphodiester linkage between two neighbouring 2′-deoxyguanosine (dG) res...
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| Publicado en: | Biochemistry |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4889123/ https://ncbi.nlm.nih.gov/pubmed/26624500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01078 |
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