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Backbone Flexibility Influences Nucleotide Incorporation by Human Translesion DNA Polymerase η Opposite Intrastrand Cross-linked DNA

Intrastrand cross-links (IaCL) connecting two purine nucleobases in DNA pose a challenge to high fidelity replication in the cell. Various repair pathways or polymerase bypass can cope with these lesions. The influence of the phosphodiester linkage between two neighbouring 2′-deoxyguanosine (dG) res...

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Publicado en:Biochemistry
Main Authors: O’Flaherty, Derek K., Guengerich, F. Peter, Egli, Martin, Wilds, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889123/
https://ncbi.nlm.nih.gov/pubmed/26624500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01078
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