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Molecular and cellular insights into T cell exhaustion
In chronic infections and cancer, T cells are exposed to persistent antigen and/or inflammatory signals. This scenario is often associated with the deterioration of T cell function: a state called ‘exhaustion’. Exhausted T cells lose robust effector functions, express multiple inhibitory receptors a...
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| Udgivet i: | Nat Rev Immunol |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4889009/ https://ncbi.nlm.nih.gov/pubmed/26205583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nri3862 |
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