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Microscale Adaptation of In Vitro Transcription/Translation for High-Throughput Screening of Natural Product Extract Libraries

Novel antimicrobials that effectively inhibit bacterial growth are essential to fight the growing threat of antibiotic resistance. A promising target is the bacterial ribosome, a 2.5 MDa organelle susceptible to several biorthogonal modes of action used by different classes of antibiotics. To promot...

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Detalhes bibliográficos
Publicado no:Chem Biol Drug Des
Main Authors: Lowell, Andrew N., Santoro, Nicholas, Swaney, Steven M., McQuade, Thomas J., Schultz, Pamela J., Larsen, Martha J., Sherman, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888872/
https://ncbi.nlm.nih.gov/pubmed/26147927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12614
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