High-Throughput Screen of Natural Product Extracts in A Yeast Model of Polyglutamine Proteotoxicity

Proteins with expanded polyglutamine (polyQ) segments cause a number of fatal neurodegenerative disorders, including Huntington’s disease (HD). Previous high-throughput screens in cellular and biochemical models of HD have revealed compounds that mitigate polyQ aggregation and proteotoxicity, provid...

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Bibliographic Details
Main Authors: Walter, Gladis M., Raveh, Avi, Mok, Sue-Ann, McQuade, Thomas J., Arevang, Carl J., Schultz, Pamela J., Smith, Matthew C., Asare, Samuel, Cruz, Patricia G., Wisen, Susanne, Matainaho, Teatulohi, Sherman, David H., Gestwicki, Jason E.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068144/
https://ncbi.nlm.nih.gov/pubmed/24636344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12259
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