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Novel Polyglutamine Model Uncouples Proteotoxicity from Aging
Polyglutamine expansions in certain proteins are the genetic determinants for nine distinct progressive neurodegenerative disorders and resultant age-related dementia. In these cases, neurodegeneration is due to the aggregation propensity and resultant toxic properties of the polyglutamine-containin...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4016013/ https://ncbi.nlm.nih.gov/pubmed/24817148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096835 |
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