Novel Polyglutamine Model Uncouples Proteotoxicity from Aging

Polyglutamine expansions in certain proteins are the genetic determinants for nine distinct progressive neurodegenerative disorders and resultant age-related dementia. In these cases, neurodegeneration is due to the aggregation propensity and resultant toxic properties of the polyglutamine-containin...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Christie, Nakeirah T. M., Lee, Amy L., Fay, Hannah G., Gray, Amelia A., Kikis, Elise A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2014
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4016013/
https://ncbi.nlm.nih.gov/pubmed/24817148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096835
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