Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia

Microglia play a pivotal role in clearance of Aβ by degrading them in lysosomes, countering amyloid plaque pathogenesis in Alzheimer’s disease (AD). Recent evidence suggests that lysosomal dysfunction leads to insufficient elimination of toxic protein aggregates. We tested whether enhancing lysosoma...

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Enregistré dans:
Détails bibliographiques
Publié dans:Protein Cell
Auteurs principaux: Bao, Jintao, Zheng, Liangjun, Zhang, Qi, Li, Xinya, Zhang, Xuefei, Li, Zeyang, Bai, Xue, Zhang, Zhong, Huo, Wei, Zhao, Xuyang, Shang, Shujiang, Wang, Qingsong, Zhang, Chen, Ji, Jianguo
Format: Artigo
Langue:Inglês
Publié: Higher Education Press 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887328/
https://ncbi.nlm.nih.gov/pubmed/27209302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-016-0269-2
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